Ethical Challenges in Adaptive and Platform Trials - The Multi-Regional Clinical Trials Center of Brigham and Women's Hospital and Harvard

Adaptive and platform trials may promise greater efficiency and scientific sophistication, but they also raise ethical questions about the principles of informed consent, clinical equipoise, and justice, in addition to practical challenges. Attendees engaged and expanded upon these ethical issues and considered strategies for addressing the theoretical and practical challenges they raise for investigators, sponsors, IRBs, participants, and other stakeholders.

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